论文部分内容阅读
目的探讨血清心型脂肪酸结合蛋白(heart fatty acid binding protein,H-FABP)在急性脑梗死(acute ischemic stroke,AIS)和脑出血(intracerebral hemorrhage,ICH)患者中的表达差异,分析其与病理特征间的关系。方法发病12h内AIS患者89例(AIS组)和ICH患者66例(ICH组),采用双抗体夹心ELISA法检测2组血清H-FABP水平,分析血清H-FABP水平与梗死部位、梗死灶大小和梗死病因分型间的关系。结果AIS组血清H-FABP水平[132.14(81.63,324.26)ng/L]与ICH组[171.35(102.86,382.65)ng/L]比较差异无统计学意义(P>0.05);AIS组和ICH组血清H-FABP水平与初始NIHSS评分均无明显相关性(r=-0.110,P=0.307;r=0.094,P=0.451);AIS组血清H-FABP水平在梗死灶大小和梗死部位上差异无统计学意义(P>0.05);心源性脑梗死患者血清H-FABP水平[263.65(126.32,627.17)ng/L]高于动脉硬化性脑梗死[115.36(82.14,232.48)ng/L]、小血管性梗死[123.06(74.95,288.82)ng/L]和其他病因梗死患者[130.43(59.88,268.10)ng/L](P<0.05)。结论血清H-FABP水平不能鉴别AIS和ICH,可能是预测心源性脑梗死的潜在分子标志物。
Objective To investigate the expression differences of serum cardiac-type fatty acid binding protein (H-FABP) in patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) Relationship between. Methods 89 patients with AIS (AIS group) and 66 patients with ICH (ICH group) within 12 hours after onset of disease were enrolled in this study. H-FABP levels were measured by double antibody sandwich ELISA in 2 groups. The levels of serum H-FABP were compared with infarct size, And the cause of the infarction between the type of relationship. Results There was no significant difference in serum H-FABP level between AIS group and ICH group [132.14 (81.63, 324.26) ng / L vs 171.35 (102.86, 382.65) ng / L in ICH group There was no significant correlation between serum H-FABP level and initial NIHSS score (r = -0.110, P = 0.307; r = 0.094, P = 0.451). The level of H-FABP in AIS group was no difference between infarct size and infarct size The level of serum H-FABP in patients with cardio-cerebral infarction [263.65 (126.32,627.17) ng / L] was higher than that of atherosclerotic cerebral infarction [115.36 (82.14,232.48) ng / L] Small vascular infarction [123.06 (74.95, 288.82) ng / L] and other causes of infarction [130.43 (59.88,268.10) ng / L] (P <0.05). Conclusion The serum H-FABP level can not distinguish AIS and ICH, which may be a potential molecular marker for predicting cardio-cerebral infarction.