论文部分内容阅读
目的研究T2DM患者的肺功能损害及其影响因素。方法选取我院100例诊断为T2DM的患者及40名健康志愿者,检测肺功能及动脉血气进行对照研究,并以肺功能各项指标与FPG、胰岛素敏感性指数(ISI)、HbA_1c、BMI和糖尿病病程等进行多因素线性回归分析。结果 (1)T2DM组BMI明显高于对照组(P<0.01)。(2)T2DM组肺总量(TLC)、用力肺活量(FVC)、1秒用力呼气量(FEV_1)、用力呼出气量为50%肺活量的最大呼气中期流量(MMEF_(50))、用力呼出气量为25%肺活量的最大呼气中期流量(MMEF_(25))明显低于对照组(P<0.01)。T2DM组一氧化碳弥散量(DLCO)、弥散指数(DLCO/VA)、动脉血氧分压(PaO_2)和血氧饱和度(SaO_2)低于对照组(P<0.01)。(3)TLC、FVC、FEV1、MMEF_(50)与FPG、2hPG、FC-P、2hC-P、HbA_1c、BMI、ISI、病程无明显相关;但DLCO、DLCO/VA、MMEF_(25)与FPG、2hPG、FC-P、2hC-P、HbA_1c、BMI、病程呈显著负相关(P<0.05或P<0.01),与ISI呈显著正相关(P<0.05)。结论 (1)T2DM患者肺功能损害主要表现为限制性通气功能障碍、小气道功能减退和弥散功能异常。(2)FPG、2hPG、FC-P、2hC-P、HbA_1c、BMI、病程、ISI与T2DM小气道损害和肺弥散功能障碍密切相关。
Objective To investigate the pulmonary function impairment and its influencing factors in T2DM patients. Methods 100 patients diagnosed as T2DM in our hospital and 40 healthy volunteers were enrolled in the study. Pulmonary function and arterial blood gas were measured and compared with the indexes of FPG, ISI, HbA 1c, BMI and Diabetes and other multi-factor linear regression analysis. Results (1) The BMI in T2DM group was significantly higher than that in control group (P <0.01). (2) The maximum expiratory flow rate (MMEF_ (50)) of 50% of vital capacity in T2DM group was assessed by TLC, forced vital capacity (FVC), forced expiratory volume (FEV_1) The maximum expiratory flow (MMEF_ (25)) of 25% vital capacity was significantly lower than that of the control group (P <0.01). DLCO, DLCO / VA, PaO_2 and SaO_2 in T2DM group were lower than those in control group (P <0.01). (3) There was no significant correlation between TLC, FVC, FEV1, MMEF50 and duration of FPG, 2hPG, FC-P, 2hC-P, HbA1c, BMI and ISI; , 2hPG, FC-P, 2hC-P, HbA_1c and BMI. There was a significant positive correlation between ISI and ISI (P <0.05 or P <0.01). Conclusions (1) Pulmonary dysfunction in patients with T2DM is mainly manifested as restrictive ventilation dysfunction, small airway dysfunction and diffuse dysfunction. (2) FPG, 2hPG, FC-P, 2hC-P, HbA_1c, BMI, duration of disease, ISI and T2DM were closely related to airway damage and pulmonary diffuse dysfunction.