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目的观察环磷腺苷葡胺对慢性充血性心力衰竭(CHF)的血胱抑素C及BNP的影响。方法 156例CHF患者被随机分为对照组(81例,常规治疗)、治疗1组(75例,常规治疗基础上加环磷腺苷葡胺)、疗程为14d。分别于用药前及给药14d后测定血浆B型利钠肽(BNP)浓度、左室射血分数(LVEF)、胱抑素C。结果两组治疗前后心功能均明显改善,与对照组比较,治疗组LVEF显著改善(P<0.05),血浆BNP、胱抑素C浓度显著降低(P<0.01),心功能进一步改善。结论环磷腺苷葡胺可改善CHF患者心功能,降低血浆BNP、胱抑素C浓度,提高LVEF,改善心脏功能,治疗CHF疗效显著。
Objective To observe the effects of cyclic adenosine monophosphate on serum cystatin C and BNP in patients with chronic congestive heart failure (CHF). Methods 156 patients with CHF were randomly divided into control group (81 cases, routine treatment), treatment group 1 (75 cases, based on conventional therapy plus cyclic adenosine monophosphate), the course of treatment was 14 days. The concentrations of plasma BNP, LVEF and cystatin C were measured before treatment and 14d after administration respectively. Results Compared with the control group, the LVEF in the treatment group was significantly improved (P <0.05). The plasma BNP and cystatin C levels were significantly lower (P <0.01) and the cardiac function was further improved. CONCLUSION Phosphoglucoside can improve cardiac function, decrease plasma BNP, cystatin C, increase LVEF and improve cardiac function in patients with CHF.