因其高患病率以及能够改变脓毒症的病理生理学关键要素,糖尿病可能是脓毒症的重要并存疾病。但是糖尿病对感染和脓毒症发展的确切影响仍没有得到证实。本文的目的在于通过回顾临床前及临床研究,来讨论糖尿病对脓毒症的病理生理学、易感性及临床预后的影响。 Diabetes mellitus may be an important co-morbid condition of sepsis due to its high prevalence and the critical pathophysiology of sepsis. However, the exact impact of diabetes on the development of infection and sepsis has not yet been confirmed. The purpose of this article is to review the impact of diabetes on the pathophysiology, susceptibility and clinical outcome of sepsis by reviewing preclinical and clinical studies.