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目的探讨血清胱蛋白酶抑制剂(CysC)对评估IgA肾病患者肾脏病理变化的价值。方法对122例IgA肾病患者应用免疫散射法检测血清CysC,同时测定血肌酐和24h尿蛋白定量;根据肾穿刺病理检查结果使用Hass分类系统衡量肾小球指数和肾间质病变程度,判定疾病进展情况。结果IgA肾病患者在肾脏病理类严重程度的增加,血清CysC水平升高,差异有显著的统计学意义(P<0.05);血肌酐水平也随病理类型严重程度升高,但差异无统计学意义(P>0.05);24h尿蛋白定量不随之升高,差异无统计学意义(P>0.05)。结论IgA肾病患者血清CysC与肾脏病理有较好的相关性,能反映IgA肾病的病理变化严重程度,可望用于临床监测。
Objective To investigate the value of serum cystatin C (CysC) in assessing renal pathological changes in patients with IgA nephropathy. Methods 122 cases of IgA nephropathy patients were detected by immunostaining CysC, serum creatinine and 24 hours urinary protein quantitation; according to the results of renal biopsy using the Hass classification system to measure the degree of glomerular index and renal interstitial disease to determine the progress of the disease Happening. Results The IgA nephropathy patients had an increased severity of renal pathology and elevated serum CysC, the difference was statistically significant (P <0.05). The serum creatinine level also increased with the severity of pathological type, but the difference was not statistically significant (P> 0.05). The urinary protein excretion in 24 hours did not increase, the difference was not statistically significant (P> 0.05). Conclusion Serum CysC in patients with IgA nephropathy has a good correlation with renal pathology, which can reflect the severity of IgA nephropathy and is expected to be used for clinical monitoring.