目的　探讨凝血酶治疗新生儿上消化道出血的临床效果。方法　对 2 0 0 0年至今收住院的新生儿上消化道出血患儿 17例 ,除常规综合疗法外 ,静脉滴注维生素K1 10mg/d ,连用 4～ 7d。结果　治疗组 17例 ,显效 16例 ,显效率 97% ,对照组 15例 ,显效 7例 ,显效率 40 % ,两组比较有明显差异性 (P <0 0 0 1)。治疗组止血时间 1 3 5± 0 6d ,对照组平均止血时间 3 2±0 5d ,两组比较有明显差异性 (P <0 0 0 1)。结论　凝血酶治疗新生儿上消化道出血为一种安全、方便 ,无副作用的首选止血药物 Objective To investigate the clinical effect of thrombin in the treatment of neonatal upper gastrointestinal bleeding. Methods Twenty-seven neonates with upper gastrointestinal bleeding admitted to the hospital from 2000 to present were given intravenous vitamin K1 10 mg / d intravenously for 4-7 days in addition to the conventional combination therapy. Results In the treatment group, 17 cases were markedly treated, 16 cases markedly effective, 97% effective rate, 15 cases in the control group, 7 cases markedly effective and 40% effective rate. There was significant difference between the two groups (P <0.01). The hemostasis time of the treatment group was 135 ± 6 days, and the mean hemostasis time of the control group was 32 ± 0.05 days. There was significant difference between the two groups (P <0.01). Conclusion Thrombin treatment of neonatal upper gastrointestinal bleeding as a safe, convenient, no side effects of the preferred hemostatic drugs