一、非选择性B—阻滞剂心得安致全身及门脉血液动力学改变。 1980年,Lebrec等报道,给门脉高压肝硬化患者口服心得安以减慢25％的静息脉率(RPR)可引起门脉压的持续下降。其将16名无黄疸、腹水或脑病的食管静脉曲张出血患者分为心得安及安慰剂两组,治疗期间测量其心搏量、肝血流量及肝静脉游离压(FHVP)及楔压(WHVP),后者可准 First, non-selective B-blockers feel safe due to systemic and portal hemodynamic changes. In 1980, Lebrec et al. Reported that oral prophylaxis of portal hypertension in patients with cirrhosis slowed down by 25% of the resting pulse rate (RPR) can cause a continuous drop in portal pressure. Sixteen patients with esophageal variceal bleeding without jaundice, ascites or encephalopathy were assigned to either placebo or placebo. Their stroke volume, hepatic blood flow, free hepatic venous pressure (FHVP) and wedge pressure (WHVP) were measured during treatment ), The latter can be accurate