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为观察应用国产乙型肝炎血源疫苗阻断经夫妻间传播乙型肝炎的作用,我们于1986年对部份HBsAg 阳性者的新婚配偶接种乙肝疫苗,3年后复查,以便评价乙肝疫苗阻断性传播乙型肝炎的效果。观察对象是江门市区1986年内登记结婚的新婚夫妇,结婚年龄18～35岁。分组:(1)暴露组:按民政局登记结婚顺序,随机抽出一方为HBsAg 阳性,另一方为HBsAg 阴性的配偶,不接种乙肝疫苗,共88对。(2)观察组:一方为HBsAg 阳性,另一方是HBsAg 阴性,并在婚前检查后HBsAg 阴性配偶接种乙肝疫苗(全程),共23对。(3)对照组:在暴露组每对夫妇后,连抽1～2对双方均为HBsAg 阴性配偶,不接种乙肝疫苗,共102对。疫苗是卫生部北京生物制品研究所生产的,批号85·3—1,每人每次上臂三角肌内注射1.0ml,蛋白含量20μg,按全程0-1-6月各注射1次。HBsAg 检测用RPHA 法;抗-HBs 测定用RIA
To observe the effect of using a domestic hepatitis B blood-borne vaccine to block the transmission of hepatitis B between husband and wife, we inoculated part-time HBsAg-positive newly-married spouses to hepatitis B vaccine in 1986 and was reviewed after 3 years in order to evaluate the hepatitis B vaccine block Sexually transmitted hepatitis B effect. Observed object is married in Jiangmen urban areas married couple in 1986, married aged 18 to 35 years. Grouping: (1) Exposed group: According to the order of marriage registered by the Civil Affairs Bureau, 88 couples were randomized to be HBsAg-positive and HBsAg-negative spouses were not vaccinated. (2) Observation group: one was HBsAg positive, the other was HBsAg negative, and 23 couples were vaccinated with HBsAg negative spouse after the prenuptial examination. (3) Control group: After exposing each group of couple, one to two pairs of patients were exposed to HBsAg-negative spouses and 102 were not vaccinated. Vaccine is produced by Beijing Institute of Biological Products, Ministry of Health, lot number 85 · 3-1, each upper arm intramuscular injection of 1.0ml, protein content 20μg, according to the whole 0-1-6 injection each time. RPHA method for detecting HBsAg; RIA for measuring anti-HBs