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AIM: To study the chemical constituents of the roots and stem bark of Kadsura coccinea. METHOD: Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. RESULTS: Two compounds were determined as(7′S,8′S,8R)-(8β,8′α)- dimethyl-4,4′-dihydroxy-5,3′-dimethoxy-5′-cyclolignan glucoside(1) and micrandiactone H(2), respectively. CONCLUSION: Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide(NO) production in lipopolysaccharide-induced RAW264.7 macrophages.
AIM: To study the chemical constituents of the roots and stem bark of Kadsura coccinea. METHOD: Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated extensive spectroscopic methods , including 1D- and 2D-NMR, and HR-ESI-MS. RESULTS: Two compounds were determined as (7’S, 8’S, 8R) dihydroxy-5,3’-dimethoxy-5’-cyclolignan glucoside (1) and micrandiactone H (2), respectively. CONCLUSION: Compunds 1 and 2 are new and neither elected inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.