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目的探讨慢性乙型肝炎患者血清中乙肝病毒脱氧核糖核酸(HBV-DNA)含量与肝功能的相关性。方法对97例慢性乙型肝炎患者血清采用荧光定量PCR方法检测HBV-DNA含量和肝功能检测结果进行比较。结果随着慢性乙肝患者血清HBV-DNA含量增高,但肝功能损害无相应的加重。结论常用的肝功能指标并不能准确的反应肝纤维化及肝脏炎症程度,而及时的检查血清HBeAg和HBV—DNA水平可直接了解乙肝患者体内HBV复制活跃程度。
Objective To investigate the relationship between serum hepatitis B virus DNA (HBV-DNA) and liver function in patients with chronic hepatitis B (HBV). Methods Serum samples from 97 patients with chronic hepatitis B were detected by fluorescence quantitative PCR to detect the content of HBV-DNA and the results of liver function tests. Results With the increase of serum HBV-DNA in patients with chronic hepatitis B, there was no corresponding increase of liver dysfunction. Conclusion Commonly used indicators of liver function can not accurately reflect the degree of liver fibrosis and liver inflammation, and timely examination of serum HBeAg and HBV-DNA levels can be directly understand the extent of HBV replication in patients with active hepatitis.