利福平是强有力的抗结核药物,主要毒副作用有肝功能损害、胃肠道反应,也可导致急性肾损害,但报道不多。笔者报告由利福平所致的12例肾损害,并结合文献进行探讨。 1 临床资料 1.1 一般资料:12例中男性7例,女性5例,最大年龄76岁,最小25岁,平均46岁。有8例在停药后再次服用时发生,4例在用药后数天至数月 Rifampicin is a powerful anti-TB drug, the main side effects of liver damage, gastrointestinal reactions, can also cause acute renal damage, but few reports. The author reported 12 cases of renal damage caused by rifampicin, combined with the literature to explore. 1 Clinical data 1.1 General information: 12 cases of 7 males and 5 females, the maximum age of 76 years, the youngest 25 years old, with an average of 46 years. 8 cases occurred again after taking the drug withdrawal, 4 cases after several days to several months