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目的了解经皮冠状动脉成形术(PTCA)对老年冠心病患者P选择素(PS)、超敏C反应蛋白(HSCRP)的变化的影响,探讨其规律及临床意义。方法60例老年冠心病患者,随机分为单纯冠脉造影(CAG)组31例,PTCA(或者行支架植入术)组29例,分别于术前、术后3h、术后3d留取静脉血标本,观察患者P选择素、HSCRP的变化。结果术前PTCA组与CAG组比较PS、HSCRP差异有统计学意义(P<0.05),术后PTCA组与术前比较均差异有统计学意义(P<0.05或者P<0.01),术后PTCA组与CAG组比较均差异有统计学意义(P<0.01)。结论PTCA可促进老年冠心病患者血小板活化,损伤内皮细胞,血栓凝集性增强,斑块稳定性下降。PS、HSCRP可作为观察冠脉斑块稳定性指标之一。
Objective To investigate the influence of percutaneous transluminal coronary angioplasty (PTCA) on the changes of P-selectin (PS) and high-sensitivity C-reactive protein (HSCRP) in elderly patients with coronary heart disease (CHD) and to explore its regularity and clinical significance. Methods Sixty elderly coronary heart disease patients were randomly divided into three groups: CAG group (n = 31) and PTCA group (n = 29). The patients were divided into two groups: preoperative, postoperative 3h and postoperative 3d, Blood samples were observed in patients with P-selectin, HSCRP changes. Results There were significant differences in PS and HSCRP between preoperative PTCA group and CAG group (P <0.05), postoperative PTCA group and preoperative difference were statistically significant (P <0.05 or P <0.01), postoperative PTCA Compared with CAG group, the difference was statistically significant (P <0.01). Conclusion PTCA can promote activation of platelet in elderly patients with coronary heart disease, damage endothelial cells, increase thrombus aggregation and decrease plaque stability. PS, HSCRP can be used as one of the indicators to observe the stability of coronary plaque.