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动态观察１６例慢性肝病患者加服硒酵母（２００μｇ硒／ｄ，连用１２周）后血浆硒水平、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性和脂质过氧化物（ＬＰＯ）含量的变化，并与未服硒制剂１６例（对照组）作比较。结果：①实验开始１２周后，对照组患者血浆硒、ＧＳＨ－Ｐｘ活性才明显增高，ＰＯ含量明显下降，与治疗前比较差异有显著性（Ｐ＜０．０５）；②服硒组患者４周后血硒、８周后ＧＳＨ－Ｐｘ活性即显著增高，１２周趋于稳定，接近正常人水平。且血硒水平均显著高于对照组同期值（Ｐ＜０．０５）；③服硒组患者８周后血ＬＰＯ含量亦显著下降。提示利用硒酵母口服提高慢性肝病患者的抗氧化能力是可行的。
Dynamic observation of plasma selenium, glutathione peroxidase (GSH-Px) activity and lipid peroxide (LPO) content in 16 patients with chronic liver disease after adding selenium yeast (200μg selenium / d for 12 weeks) The changes were compared with 16 cases without selenium preparation (control group). Results: ① After 12 weeks, the activity of selenium and GSH-Px in the control group was significantly higher than that in the control group (P <0.05), while the content of PO in the control group was significantly decreased Blood selenium after weeks, GSH-Px activity was significantly increased after 8 weeks, 12 weeks tends to be stable, close to the normal level. Blood selenium levels were significantly higher than the control group (P <0.05); ③ Serum LPO levels in the selenium group were significantly decreased after 8 weeks. Prompt use of selenium yeast oral anti-oxidation in patients with chronic liver disease is feasible.