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Ⅱ型糖病绝大多数起病隐匿,发展缓慢,多年以后可引起全身的小动脉硬化病变,肾脏为主要受累的靶器官之一。我们联合检测和比较常规尿检蛋白阴性,尿糖阳性Ⅱ型糖尿病患者的尿视醇结合蛋白（RBP）,尿微量白蛋白（mALB）,β2-微球蛋白（β2-MG）,以探讨Ⅱ型糖尿病患者肾小管早期损害的监控指标。1 材料与方法1.1 研究对象 Ⅱ型糖尿病70例均按1985年WHO关于糖尿病诊断和分型标准确定所有病例均来自本院住院和门无合并感染,无心、肺、肝功能不全和脑血管意外。根据Ⅱ型糖尿病的病程将病人分为三组:Ⅰ组Ⅱ型糖尿病的病程<10年,共25例,男13例,女12例,年龄36-74岁,Ⅱ组Ⅱ型糖尿病10-20年,共26例,另14例,女12例,年龄42-74岁;Ⅱ组Ⅱ型尿病10-20年,共26例,男10例,女9例,年龄50-74岁;对照组为50名体检健康的职工。以空服抽静脉血和检测尿有关项目。
Type â ... ¡glycoma most insidious onset, slow development, after many years can cause systemic arteriosclerosis lesions, the kidney is one of the main target organs involved. We combined detection and comparison of urinalysis alcohol binding protein (RBP), urinary microalbumin (mALB) and β2-microglobulin (β2-MG) in patients with normal urinalysis and urine glucose-positive type II diabetes to explore the relationship between type Ⅱ Early indicators of renal tubular damage in diabetic patients. 1 Materials and Methods 1.1 Subjects All 70 cases of type 2 diabetes were diagnosed by the WHO in 1985 according to the diagnosis and typing criteria to determine all cases were hospitalized in our hospital and without complications, no heart, lung, liver insufficiency and cerebrovascular accident. Patients were divided into three groups according to the duration of type 2 diabetes: Group Ⅰ The duration of type Ⅱ diabetes was less than 10 years, with a total of 25 cases, 13 males and 12 females, aged 36-74 years. Group Ⅱ diabetes mellitus 10-20 Year, a total of 26 cases, the other 14 cases, 12 females, aged 42-74 years; Ⅱ group of type 10 diabetes mellitus 10-20 years, a total of 26 cases, 10 males and 9 females, aged 50-74 years; control Group of 50 health examination workers. To empty clothes pumping venous blood and urine testing related items.