Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a worldwide severe coronavirus disease 2019(COVID-19)pandemic since December 2019.There is a great demand for effective therapies for the prevention and treatment of COVID-19.Developing therapeutic neutralizing antibodies(NAbs),which could block viral infection,is such a promising approach,as NAbs have been successfully applied to the treatment of other viral infections.The recent advances of antibody technology have greatly accelerated the discovery of SARS-CoV-2 NAbs,and many of which are now actively tested in clinical trials.Here,we re-view the approaches applied for SARS-CoV-2 NAb development,and discuss the emerging technologies underlining the antibody discovery.We further summarize the common features of these antibodies including the shared neutralizing epitopes and se-quence features.