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目的通过动态观察脐血、新生儿、脑瘫患儿血清白细胞介素-10(Interleukin-10,IL-10)水平的变化与脑损伤及预后的关系。方法采用双抗体夹心酶联免疫吸附试验法(ABC-ELISA)检测脑瘫组、脑瘫高危因素胎儿组(胎儿脐血病例组)、新生儿组(新生儿病例组)及相应对照组血清IL-10水平。结果胎儿脐血病例组血清IL-10水平与胎儿脐血对照组比较有统计学差异(P<0.01),新生儿病例组血清IL-10水平高于新生儿对照组(P<0.01);脑瘫组血清IL-10水平明显高于脑瘫对照组(P<0.01),脑瘫组血清IL-10水平明显高于新生儿病例组、胎儿脐血病例组(P<0.01)。结论 IL-10可以作为急性应激的生物学指标;IL-10水平反映脑损伤的严重程度,监测IL-10对预防和治疗脑瘫具有重要的临床意义。
Objective To observe the relationship between serum interleukin-10 (IL-10) and brain injury and prognosis in cord blood, neonates and children with cerebral palsy by dynamic observation. Methods Serum IL-10 levels in cerebral palsy group, high risk group with cerebral palsy (fetal cord blood group), neonatal group (neonatal group) and corresponding control group were detected by ABC-ELISA. Level. Results Serum levels of IL-10 in fetal cord blood were significantly higher than those in fetal cord blood (P <0.01), serum IL-10 in newborns was higher than that in neonates (P <0.01) The level of serum IL-10 in cerebral palsy group was significantly higher than that in cerebral palsy control group (P <0.01). The level of IL-10 in cerebral palsy group was significantly higher than that in neonatal group and fetal cord blood group (P <0.01). Conclusion IL-10 can be used as biological indicators of acute stress; IL-10 level reflects the severity of brain injury, monitoring IL-10 for the prevention and treatment of cerebral palsy has important clinical significance.