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强心甙类药物是小儿治疗心衰首选药物,其安全范围较小,有资料报道治疗量约为中毒量的60%。如果治疗中不注意,常产生药物中毒或其他许多付作用,故用药时应注意下列问题。一、不合理联合用药不合理的联合用药是引起中毒或降低效应最常见的原因。地戈辛中毒患儿中有27.5～50%是合并用药引起的,是为影响强心甙类药物吸收、分布、代谢及排泄过程,导致协同或拮抗的结果。若药物血液浓度过高,则产生中毒症状;药物血液浓度过低,不能有效地发挥强心甙类药物的作用。 1.减少强心甙药物吸收药物:常用的强心
Cardiac glycosides drugs for the treatment of heart failure in children, the less secure, there are data reported that the treatment of about 60% of the amount of poisoning. If you do not pay attention to treatment, often resulting in drug poisoning or many other pay, so medication should pay attention to the following questions. First, unreasonable combination of unreasonable combination of drugs is the most common cause of poisoning or reduce the effect. Geoxin poisoning in children with 27.5 to 50% is caused by the combination of medication is to affect the cardiac glycosides absorption, distribution, metabolism and excretion process, leading to synergistic or antagonistic results. If the drug blood concentration is too high, then the symptoms of poisoning; drug blood concentration is too low, can not effectively exert the role of cardiac glycosides. 1. Reduce cardiac glycoside drug absorption drugs: commonly used cardiac