本实验研究利用细粒棘球蚴（Ｅｃｈｉｎｏｃｏｃｃｕｓｇｒａｎｕｌｏｓｕｓ）囊内容物及其提纯抗原复制过敏反应模型。将１００只昆明种小白鼠，根据决定性注射致敏原的不同，随机分为羊源囊液抗原组、羊源囊液部分纯化抗原组、人源囊液抗原组和人源囊液部分纯化抗原组，并设立生理盐水对照组。以腹腔注射方式进行攻击，复制出小白鼠过敏反应模型。结果表明，四个致敏原组过敏反应发生率分别为９４．４％、８９．５％、９５％和９４．４％，而对照组则无一例发生过敏反应。同时，各组决定性注射前后分别进行血嗜酸性粒细胞直接计数，并与健康小白鼠对照，发现过敏反应发生后血中嗜酸性粒细胞计数明显升高（Ｐ＜０．０５）。提示该模型症状典型，方法简单，有较高的应用价值 In this study, the use of Echinococcus granulosus capsule content and purification of antigen replication allergic reaction model. 100 Kunming mice were randomly divided into sheep cyst fluid antigen group, sheep cyst fluid partially purified antigen group, human cyst fluid antigen group and human cyst fluid partially purified antigen according to the difference of the determinant injection allergens Group, and set up saline control group. To attack by intraperitoneal injection, replicate mouse allergic reaction model. The results showed that the incidence of allergic reactions in the four allergens was 94.4%, 89.5%, 95% and 94.4% respectively, while none of the four allergens were allergenic in the control group. At the same time, blood eosinophils were counted directly before and after critical injection in each group, and compared with healthy mice, the blood eosinophil count was significantly increased after the occurrence of allergic reaction (P <0.05). Prompted the typical symptoms of the model, the method is simple, has a high value