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目的了解铜绿假单胞菌的药物敏感性(药敏)与头孢哌酮-舒巴坦等抗菌药物用药频度的相关性,为临床合理用药提供依据。方法分别统计我院2002—2008年头孢哌酮-舒巴坦等抗菌药物用药频度和铜绿假单胞菌的药敏,采用SPSS13.0统计软件用Sperman’s相关法对2种变量进行相关性分析。结果抗菌药物中头孢哌酮-舒巴坦耐药率最低,但2008年比2002年中敏率上升了291.0%,敏感率则呈下降趋势。相关性研究结果显示:头孢哌酮-舒巴坦的中敏率与哌拉西林-三唑巴坦、头孢哌酮-舒巴坦、3代头孢类用药频度呈正相关(r=0.857,P<0.05;r=0.929,P<0.01;r=0.786,P<0.05);头孢哌酮-舒巴坦的敏感率与本药、美罗培南、3代头孢类含酶抑制药用药频度呈负相关(r=-0.821,P<0.05;r=-0.786,P<0.05;r=-0.786,P<0.05),与头孢他啶、阿米卡星、左氧氟沙星(0.5g)用药频度呈正相关(r=0.821,P<0.05;r=0.929,P<0.01;r=1.000,P<0.01);左氧氟沙星(0.5g)用药频度分别与环丙沙星、阿米卡星、左氧氟沙星以及头孢哌酮-舒巴坦耐药率呈完全负相关(r=-1.000,P<0.01;r=-1.000,P<0.01;r=-1.000,P<0.01;r=-1.000,P<0.01);美罗培南耐药率与亚胺培南-西司他丁、哌拉西林-三唑巴坦、头孢吡肟耐药率呈完全正相关(r=1.000,P<0.01;r=1.000,P<0.01;r=1.000,P<0.01);头孢他啶和氨曲南的耐药率与其他药物用药频度及耐药率也有相关性。结论头孢哌酮-舒巴坦等抗菌药物的药敏与用药频度存在显著的相关性,近期临床应注意调整抗菌药物用药频度。
Objective To understand the relationship between the drug sensitivity (susceptibility) of Pseudomonas aeruginosa and the frequency of antibacterials such as cefoperazone-sulbactam and so on, and to provide basis for clinical rational drug use. Methods The frequency of antibacterials such as cefoperazone-sulbactam and the susceptibility of Pseudomonas aeruginosa in our hospital from 2002 to 2008 were analyzed respectively. The correlation analysis of two variables was conducted by Sperman’s correlation using SPSS 13.0 statistical software . Results The antibacterial drug cefoperazone - sulbactam resistance rate of the lowest, but in 2008 than in 2002, the sensitivity rate increased by 291.0%, the sensitivity rate showed a downward trend. Correlation analysis showed that the frequency of cefoperazone-sulbactam was positively correlated with the frequency of piperacillin-tazobactam, cefoperazone-sulbactam and third-generation cephalosporins (r = 0.857, P <0.05; r = 0.929, P <0.01; r = 0.786, P <0.05). The frequency of cefoperazone-sulbactam was negatively correlated with the frequency of drug use inhibition of the drug, meropenem and 3rd generation cephalosporins (R = -0.821, P <0.05; r = -0.786, P <0.05; r = -0.786, P <0.05) and was positively correlated with the dosage of ceftazidime, amikacin and levofloxacin = 0.821, P <0.05; r = 0.929, P <0.01; r = 1.000, P <0.01); the dosage of levofloxacin (0.5g) was significantly higher than that of ciprofloxacin, amikacin, levofloxacin and cefoperazone- Sulbactam resistance rate was negatively correlated (r = -1.000, P <0.01; r = -1.000, P <0.01; r = -1.000, P <0.01; r = -1.000, P <0.01) There was a positive correlation between drug resistance rate and the resistance rates of imipenem-cilastatin, piperacillin-tazobactam and cefepime (r = 1.000, P <0.01; r = 1.000, r = 1.000, P <0.01). The resistance rates of ceftazidime and aztreonam are also related to the frequency of drug use and drug resistance. Conclusions Cefoperazone - sulbactam antibacterial drugs such as drug susceptibility and frequency of medication there is a significant correlation, the recent clinical should pay attention to adjust the frequency of antimicrobial medication.