目的:观察氨茶碱和纳洛酮联合治疗极低出生体重儿呼吸暂停的临床疗效。方法:将130例极低出生体重儿随机分为对照组64例和观察组66例,均用氨茶碱(3 mg/kg·次Q12 h)治疗,观察组加用纳洛酮(0.1 mg/kg·次Q12 h),两组均是微量泵2 h内滴完,连用4天。比较两组48 h内和48～72 h呼吸暂停的次数和时间差异。结果:观察组48 h内显效48例(72.7%),48～72 h内有效16例(24.2%),总有效率97%;对照组48 h内显效30例(46.9%),48～72 h内有效17例(26.6%),总有效率73%。观察组在48 h内显效明显优于对照组(χ2=7.59,P<0.01),两组的总有效率有显著差异性(χ2=11.6,P<0.01)。结论:氨茶碱和纳洛酮联合应用治疗极低出生体重儿的呼吸暂停疗效高于单用氨茶碱患儿。 Objective: To observe the clinical efficacy of aminophylline and naloxone combined with apnea for very low birth weight infants. Methods: A total of 130 children with very low birth weight were randomly divided into control group (64 cases) and observation group (66 cases), all treated with aminophylline (3 mg / kg Q12 h) / kg • times Q12 h), both groups were micro-pump within 2 hours drip finished, once every 4 days. The differences in number and time of apnea between 48 h and 48 h were compared between the two groups. Results: In the observation group, 48 cases (72.7%) were markedly effective within 48 h, 16 (24.2%) effective within 48-72 h, and the total effective rate was 97%. In the control group, 30 cases (46.9%) and 48-72 h effective in 17 cases (26.6%), the total effective rate of 73%. The observation group was significantly better than the control group within 48 h (χ2 = 7.59, P <0.01), the total effective rate was significantly different (χ2 = 11.6, P <0.01). CONCLUSION: The combination of aminophylline and naloxone in the treatment of very low birth weight infants with apnea is more effective than aminophylline alone.