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Tumor-induced osteomalacia(TIO) is caused by a small mesenchymal tumor and characterized by hypophosphatemia, phosphaturia, low levels of 1,25(OH)_2 vitamin D, and elevated levels of alkaline phosphatase and fibroblast growth factor 23(FGF-23). The typical symptoms include bone pain, pseudofracture, osteoporosis, and muscle weakness. These symptoms are due to the overproduction of FGF-23 as a phosphaturic agent. Diagnosis of this disease is challenging because of the small lesion size and chronic symptoms. The cases described in this report were two patients with bone pain, severe muscle weakness, and difficulty performing activities, who were found to have TIO. The tumors were found through various imaging modalities, including computed tomography(CT), magnetic resonance imaging(MRI), and positron emission tomography(PET). The tumors responsible for the symptoms were localized on their femurs and resection resulted in normalization of their blood chemistries and complaints.
Tumor-induced osteomalacia (TIO) is caused by a small mesenchymal tumor and characterized by hypophosphatemia, phosphaturia, low levels of 1,25 (OH) 2 vitamin D, and elevated levels of alkaline phosphatase and fibroblast growth factor 23 (FGF- . The typical symptoms include bone pain, pseudofracture, osteoporosis, and muscle weakness. These symptoms are due to the overproduction of FGF-23 as a phosphaturic agent. Diagnosis of this disease is challenging because of the small lesion size and chronic symptoms. The cases described in this report were two patients with bone pain, severe muscle weakness, and difficulty performing activities, who were found to have have TIO. The tumors were found through various imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET). The tumors responsible for the symptoms were localized on their femurs and resection resulted in normalization of their blood chemistries and complaints.