论文部分内容阅读
目的分析胃癌累及食管伴纵隔淋巴结转移的临床病理特征。方法回顾1970年至1999年30年间收治的胃癌累及食管下段同时伴纵隔淋巴结转移的手术患者63例,进行单变量与多变量分析,确定其预后因素。结果1、3、5年生存率分别为47.3%、10.6%、8.0%。除纵隔以外的淋巴结转移情况、肿瘤浸润深度与肝脏转移是独立的预后因素。结论胃癌累及食管伴纵隔淋巴结转移预后非常差,但只要条件允许,对该类患者进行保证切缘的切除加包括下纵隔在内的适当淋巴结清扫,可能使部分患者,特别是没有肝脏转移及浆膜浸润、不合并除纵隔以外远处淋巴结转移的患者受益。
Objective To analyze the clinicopathological features of gastric cancer involving esophageal and mediastinal lymph node metastasis. Methods A retrospective study of 63 patients with gastric cancer involving the lower esophagus and mediastinal lymph node metastasis from 1970 to 1999 was conducted. Univariate and multivariate analyzes were performed to determine the prognostic factors. Results The 1-, 3- and 5-year survival rates were 47.3%, 10.6% and 8.0% respectively. In addition to mediastinal lymph node metastases, tumor invasion depth and liver metastasis are independent prognostic factors. Conclusions The prognosis of gastric cancer involving esophageal and mediastinal lymph node metastasis is very poor. However, as long as the conditions permit, excision of margins and appropriate lymph node dissection, including the mediastinum, may be performed in some patients, especially in the absence of liver metastasis and plasma Membrane infiltration does not benefit patients with distant lymph node metastases beyond the mediastinum.