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目的研究中性粒细胞淋巴细胞比值(NLR)在溃疡性结肠炎(UC)诊断及疾病活动度监测中的价值。方法 121例溃疡性结肠炎患者作为病例组,122例年龄及性别匹配的健康受试者作为对照组。病例组患者根据改良的Mayo评分系统分为活动组(59例)和缓解组(62例)。检测各组血常规,比较各组NLR、中性粒细胞(N)、淋巴细胞(L)计数。结果活动组外周血NLR、N计数均明显高于缓解组、对照组;L计数低于缓解组、对照组(P<0.05)。构建ROC曲线,AUC及95%CI分别为0.801(0.722~0.880),cutoff值取2.68提示UC活动时,敏感性为74.1%,特异性为72.9%。结论 NLR可作为临床诊断UC及判断疾病活动有价值的指标。
Objective To investigate the value of neutrophil lymphocyte ratio (NLR) in the diagnosis of ulcerative colitis (UC) and disease activity monitoring. Methods 121 cases of ulcerative colitis patients as a case group, 122 age and gender-matched healthy subjects as a control group. Patients in the case group were divided into active group (n = 59) and remission group (n = 62) according to the modified Mayo scoring system. Blood samples were collected and the NLR, neutrophil (N) and lymphocyte (L) counts of each group were compared. Results The counts of NLR and N in peripheral blood of patients in active group were significantly higher than that of remission group and control group. L count was lower than that of remission group and control group (P <0.05). The ROC curve was constructed. The AUC and 95% CI were 0.801 (0.722-0.880) respectively. The cutoff value was 2.68. The sensitivity and specificity of UC were 74.1% and 72.9% respectively. Conclusion NLR can be used as a valuable index in clinical diagnosis of UC and disease activity.