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目的观察人血丙种球蛋白治疗手足口病合并脑炎的疗效。方法将60例手足口病合并脑炎患儿随机分为治疗组及对照组,两组病例的年龄、性别、临床症状、病程、脑脊液检查经统计学分析差异无统计学意义(P>0.05),两组患儿均予降颅压,抗病毒,激素等对症支持治疗,治疗组应用人血丙种球蛋白1g/(kg·d),连用2d,对两组治疗进行临床比较。结果治疗组主要症状、体征的缓解及住院天数较对照组明显缩短,脑脊液恢复时间均较对照组短,差异有统计学意义(P<0.05)。结论人血丙种球蛋白治疗手足口病合并脑炎能迅速改善症状、缩短病程,改善预后,治疗手足口病合并脑炎疗效确切,值得临床推广应用。
Objective To observe the therapeutic effect of human gamma globulin on HFMD complicated with encephalitis. Methods Sixty children with hand, foot and mouth disease complicated with encephalitis were randomly divided into treatment group and control group. There was no significant difference in age, gender, clinical symptoms, course of disease and cerebrospinal fluid between the two groups by statistical analysis (P> 0.05) , Both groups were given intracranial pressure, anti-virus, hormones and other symptomatic and supportive treatment. The treatment group was given 1g / (kg · d) of human blood gammaglobulin for 2 days. The clinical comparisons were made between the two groups. Results The main symptoms, signs and hospitalization days in the treatment group were significantly shorter than those in the control group, and the recovery time of CSF was shorter than that in the control group (P <0.05). Conclusions Human hemagglutinin in the treatment of hand, foot and mouth disease with encephalitis can rapidly improve the symptoms, shorten the course and improve the prognosis. The treatment of hand, foot and mouth disease with encephalitis is effective and worthy of clinical application.