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本文报告中药葛根有效成分之一黄豆甙元及其一系列衍生物和33个异黄酮类似物的合成及增强缺氧耐力的实验,化合物Ⅰ_2、Ⅰ_(13)、Ⅰ_(21)抗缺氧作用优于黄豆甙元Ⅰ_2;并对结构与抗缺氧活性间关系进行了探讨,初步发现4′位取代对活性有明显影响,醚基取代较好,2位氢为甲基取代或7位羟基被氢取代后活性消失。
In this paper, the synthesis of daidzein, a series of derivatives and 33 isoflavone analogues, and the study of hypoxia and endurance enhancement were reported in this paper. The effects of compounds Ⅰ_2, Ⅰ_ (13) and Ⅰ_ (21) Which was superior to daidzein Ⅰ_2. The relationship between structure and anti-anoxic activity was discussed. It was found that the substitution of 4’-position had a significant effect on the activity, the substitution of ether group was better, the hydrogen at position 2 was methyl-substituted or the hydroxyl group at position 7 Reactivity disappeared after hydrogen substitution.