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目的 :了解Azone对丹参浸膏中丹参素的透皮促渗作用。方法 :采用离体裸鼠皮肤 ,应用Franz扩散池进行体外渗透实验 ,计算丹参素累积渗透量、渗透系数。结果 :Azone不同用量 ,不同时间的预处理均有明显促渗作用。渗透方程均为零级模式。结论 :促渗剂预处理是一种较好的促渗方法。
Objective : To understand the transdermal effect of Azone on Danshensu in Danshen extract. Methods :In vitro nude mice skin was used for in vitro permeation experiments using Franz diffusion cell to calculate the cumulative permeation and permeability coefficients of Danshensu. Results : Azone with different dosages and pretreatments at different times had significant permeation. Osmotic equations are all zero-order modes. Conclusion : Pretreatment with penetration enhancer is a good method for promoting penetration.