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目的 探讨急性心肌梗塞(AMI)血清可溶性细胞间粘附分子(SICM-1)的变化及临床意义.方法 采用ELISA法测定了30例AMI患者血清SICAM-1,并与30例不稳定心绞痛(UAP)和30例正常人进行比较.结果AMI发生后24小时内血清sICAM-1明显高于UAP和正常对照组(P<0.001),梗塞面积越大,sICAM—1升高越明显.AMI发生后7日内,sICAM—1呈上升趋势,7～14天sICAM-1开始下降,14天仍高于其余两组.结论 血清sICAM-1与AMI发生及梗塞面积呈正相关,可作为AMI病情变化的观察指标之一.
Objective To investigate the changes and clinical significance of serum soluble intercellular adhesion molecule (SICM-1) in patients with acute myocardial infarction (AMI) .Methods The serum levels of SICAM-1 in 30 patients with AMI were measured by ELISA and 30 patients with unstable angina (UAP ) And 30 normal subjects.Results Serum sICAM-1 was significantly higher in 24 hours after AMI than in UAP and normal control group (P <0.001) SICAM-1 began to decline within 7 to 14 days and remained higher than the other two groups within 14 days.Conclusion Serum sICAM-1 is positively correlated with the occurrence and infarct size of AMI and may be used as an observation of the change of AMI One of the indicators.