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目的探讨复方α-酮酸片(开同)治疗透析患者低蛋白血症的临床疗效。方法选取2012年5月—2013年5月成都铁路分局医院收治的低蛋白血症透析患者56例,随机分为对照组与观察组,各28例。对照组患者予以常规蛋白饮食;观察组在对照组基础上加用开同。观察两组患者治疗前后前清蛋白、血清清蛋白、血红蛋白、转铁蛋白、血清胆固醇、肌酐、三酰甘油、尿素氮水平。结果治疗前两组患者前清蛋白、血清清蛋白、血红蛋白、转铁蛋白、血清胆固醇、肌酐、三酰甘油、尿素氮水平比较,差异无统计学意义(P>0.05),治疗后观察组患者前清蛋白、血清清蛋白、血红蛋白、转铁蛋白水平高于对照组,血清胆固醇、肌酐、三酰甘油、尿素氮水平低于对照组,差异有统计学意义(P<0.05);对照组患者治疗前后前清蛋白、血清清蛋白、血红蛋白、转铁蛋白、血清胆固醇、肌酐、三酰甘油、尿素氮水平比较,差异无统计学意义(P>0.05),观察组患者治疗后前清蛋白、血清清蛋白、血红蛋白、转铁蛋白水平高于治疗前,血清胆固醇、肌酐、三酰甘油、尿素氮水平低于治疗前,差异有统计学意义(P<0.05)。结论开同治疗透析患者低蛋白血症的临床疗效显著,可补充患者体内必需氨基酸及相应的酮酸,提高必需氨基酸水平,合成氨基酸,减少蛋白质分解,增加尿素氮的利用,纠正负氮平衡,改善患者营养状况。
Objective To investigate the clinical efficacy of compound α-ketoacid tablets (KT) in the treatment of hypoproteinemia in dialysis patients. Methods Fifty-six patients with hypoalbuminemia who were admitted to Chengdu Railway Branch Hospital from May 2012 to May 2013 were randomly divided into control group and observation group, with 28 cases in each group. Patients in the control group were given routine protein diet; the observation group was added on the basis of the control group. The levels of serum albumin, serum albumin, hemoglobin, transferrin, serum cholesterol, creatinine, triglyceride and urea nitrogen before and after treatment in both groups were observed. Results Before treatment, there was no significant difference in serum albumin, serum albumin, hemoglobin, transferrin, serum cholesterol, creatinine, triglyceride and urea nitrogen between the two groups before treatment (P> 0.05) Pre-albumin, serum albumin, hemoglobin, transferrin levels were higher than the control group, serum cholesterol, creatinine, triglyceride and urea nitrogen levels were lower than the control group, the difference was statistically significant (P <0.05) There was no significant difference in serum albumin, serum albumin, hemoglobin, transferrin, serum cholesterol, creatinine, triglyceride and urea nitrogen between the two groups before and after treatment (P> 0.05) Serum albumin, hemoglobin, transferrin levels were higher than before treatment, serum cholesterol, creatinine, triglyceride, urea nitrogen levels were lower than before treatment, the difference was statistically significant (P <0.05). Conclusions The clinical effect of treatment of dialysis patients with hypoalbuminemia is significant. It can supplement essential amino acids and corresponding keto acids in patients, increase essential amino acids, synthesize amino acids, reduce protein decomposition, increase the utilization of urea nitrogen, correct negative nitrogen balance, Improve patient nutrition.