本文观察了肾衰Ⅰ号汤对腺嘌呤所致慢性肾衰大鼠肾脏病变及相关状况影响。并与目前治疗慢性肾功能衰竭的药物尿毒清颗粒剂进行了对照。结果表明 :肾衰Ⅰ号汤预防组与治疗组具有显著降低腺嘌呤所致CRF大鼠BUN、血Cr、血ET ,肾重 /体重比值 ,升高血Ca/P比值 ,减轻腺嘌呤对大鼠的肾脏病理损害作用 ,其疗效接近尿毒清。提示肾衰Ⅰ号汤可有效的防治慢性肾衰的发生发展 ,推测肾衰Ⅰ号汤的作用机理可能是通过改善肾功能 ,控制蛋白尿 ,拮抗血中内皮素对肾脏的损害作用 ,抑制肾脏肥大 ,调节Ca、P代谢而实现的 This article has observed the effect of Shenshuai No. 1 Decoction on renal pathological changes and related status in chronic renal failure rats induced by adenine. And compared with the current treatment of chronic renal failure drug uremic clear granules. The results showed that: Shenshuai I decoction prophylaxis group and treatment group significantly reduced BUN, blood Cr, blood ET, kidney weight/body weight ratio, increased blood Ca/P ratio, reduced adenine to large in CRF rats induced by adenine. Rat kidney pathological damage, its efficacy is close to urinary clearance. It is suggested that Shenshuai No. 1 soup can effectively prevent the occurrence and development of chronic renal failure. It is speculated that the mechanism of action of Renshao No. 1 soup may be to improve kidney function, control proteinuria, antagonize the damage of renal endoplasmin in blood, and inhibit the kidneys. Hypertrophy, regulating Ca, P metabolism and achieved