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目的:研究分析米非司酮联合甲氨蝶呤(MTX)对异位妊娠的临床疗效及安全性。方法:选择2008年1月-2010年1月期间本院收治的40例异位妊娠患者作为临床试验研究对象,随机分为两组。对照组患者单纯采用甲氨蝶呤进行治疗;实验组患者采用米非司酮联合甲氨蝶呤进行治疗,对比两组患者的临床疗效。结果:实验组患者的治愈率明显高于对照组,P<0.05,差异具有统计学意义;实验组患者的血β-HCG值在用药5d后开始明显下降,对照组患者的血β-HCG值在用药10d后开始明显下降,组间对比具有显著差异,P<0.05,有统计学意义;实验组患者的不良反应发生率明显低于对照组,P<0.05,差异具有统计学意义。结论:对异位妊娠患者使用米非司酮联合甲氨蝶呤的治疗方式具有安全性高、不良反应小、经济性强等诸多优点,并且治疗效果显著,是一种值得临床上广泛推广应用的保守性治疗手段。
Objective: To study the clinical efficacy and safety of mifepristone combined with methotrexate (MTX) on ectopic pregnancy. Methods: Forty cases of ectopic pregnancy admitted to our hospital from January 2008 to January 2010 were selected as clinical trials and randomly divided into two groups. Patients in the control group were treated with methotrexate alone. Patients in the experimental group were treated with mifepristone combined with methotrexate, and the clinical efficacy was compared between the two groups. Results: The cure rate of the experimental group was significantly higher than that of the control group, P <0.05, the difference was statistically significant; the experimental group of patients with blood β-HCG values began to decline significantly 5d after treatment, the control group of patients with β-HCG P <0.05, there was a significant difference; the incidence of adverse reactions in the experimental group was significantly lower than that in the control group, P <0.05, the difference was statistically significant. Conclusion: The treatment of mifepristone combined with methotrexate in patients with ectopic pregnancy has many advantages, such as high safety, little adverse reaction, strong economy and so on, and it is worth to be widely applied clinically Conservative treatment.