目的探讨低出生体重儿发生的影响因素及综合干预对其干预效果。方法选择义乌市妇幼保健院新生儿科2013年1月-2015年12月收治的100例低出生体重儿作为观察组,100例正常出生体重儿作为对照组。在观察组中选择80例符合研究标准的低出生体重儿进行综合干预,将其随机分为干预组(40例)和未干预组(40例),未干预组给予常规治疗,干预组在常规治疗的基础上给予综合干预。结果观察组Apgar评分低于对照组(P<0.05),观察组并发症发生率高于对照组(P<0.05)。单因素分析显示:观察组的孕周低于对照组(P<0.05),观察组的早产、异常孕产史、早产史、妊娠期高血压疾病、胎膜早破的发生率高于对照组(P<0.05),观察组首次产检孕周≤13周、产检次数≥8次者所占比例低于对照组(P<0.05)。多因素分析显示:孕周、异常孕产史、妊娠期高血压疾病、首次产检孕周、首次产检次数和胎膜早破为低出生体重儿的独立影响因素(P<0.05)。干预组新生儿体重和日体重增加均高于未干预组(P<0.05),干预组身高、头围和胸围高于未干预组,但差异无统计学意义(均P>0.05)。结论孕周、异常孕产史、妊娠期高血压疾病、首次产检孕周和首次产检次数、胎膜早破为低出生体重儿的独立影响因素,对低出生体重儿进行综合干预能够显著增加新生儿的体重。 Objective To investigate the influencing factors of low birth weight infants and the effect of comprehensive intervention on them. Methods 100 cases of low birth weight infants in Yiwu MCH hospital from January 2013 to December 2015 were selected as observation group and 100 normal birth weight infants as control group. In the observation group, 80 low-birth-weight children who meet the research criteria were selected for comprehensive intervention. They were randomly divided into intervention group (40 cases) and non-intervention group (40 cases) The treatment is given on the basis of comprehensive intervention. Results The Apgar score of the observation group was lower than that of the control group (P <0.05). The complication rate of the observation group was higher than that of the control group (P <0.05). Univariate analysis showed that the gestational age of the observation group was lower than that of the control group (P <0.05). The incidence of premature birth, abnormal pregnancy history, premature birth history, hypertensive disorder of pregnancy and premature rupture of membranes in the observation group were higher than those in the control group (P <0.05). The first trimester of pregnancy in the observation group was less than 13 weeks and the number of times of more than 8 times was lower than that of the control group (P <0.05). Multivariate analysis showed that gestational age, history of abnormal pregnancy, hypertensive disorder complicating pregnancy, gestational age at first examination, number of first examinations and premature rupture of membranes were the independent influencing factors of low birth weight infants (P <0.05). The body weight and daily body weight of infants in intervention group were higher than those in non-intervention group (P <0.05). The height, head circumference and chest circumference in intervention group were higher than those in non-intervention group (all P> 0.05). Conclusion The gestational weeks, abnormal pregnancy history, hypertensive disorder complicating pregnancy, gestational age and the number of first examinations, and premature rupture of membranes are the independent influencing factors of low birth weight infants. The comprehensive intervention for low birth weight infants can significantly increase the freshmen Children’s weight.