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巨噬细胞作为重要的免疫细胞,广泛参与机体免疫应答、炎症、组织重塑、衰老等多种病理生理过程。这些活动可能是通过巨噬细胞表面表达的一系列受体分子介导的。这些分子受体包括活化性受体和抑制性受体。配对免疫球蛋白样受体B(PIR-B)作为细胞表面的一种抑制性受体广泛表达于巨噬细胞、B细胞、淋巴细胞等细胞表面。目前,对于巨噬细胞表面受体,包括PIR-B等研究较少,推测PIR-B可能在巨噬细胞参与炎症、移植免疫耐受、组织纤维化等生理过程中发挥重要的调节作用。本文就PIR-B对巨噬细胞的调节作用及其可能机制作简要综述。
As an important immune cell, macrophages are widely involved in various pathophysiological processes such as immune response, inflammation, tissue remodeling and aging. These activities may be mediated through a series of receptor molecules expressed on the surface of macrophages. These molecular receptors include both activating and inhibitory receptors. Paired immunoglobulin-like receptor B (PIR-B) is widely expressed on the surface of macrophages, B cells and lymphocytes as an inhibitory receptor on the cell surface. At present, there are few studies on the surface receptors of macrophages, including PIR-B. It is speculated that PIR-B may play an important regulatory role in the physiological processes of macrophages involved in inflammation, transplantation immune tolerance and tissue fibrosis. In this paper, the regulation of PIR-B on macrophages and its possible mechanism are briefly reviewed.