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1986年,癌症研究的先驱雷纳托·杜尔贝科(Renato Dulbecco)在《科学》杂志上宣称:“如果我们希望更多地认识癌症,那么我们现在必需集中精力研究细胞的基因组。我们正处在一个转折点上。”这位诺贝尔奖获得者20多年前的这几句话,是日后成为了人类基因组工程的一次最早的公开倡议。前些年累积的研究成果已经让人明白,癌细胞的大量越轨行为大都来源于对细胞基因造成的损伤以及功能的改变。他写道“:我们有两种选择,要么尝试逐个地去发现对恶性肿瘤起重要作用的基因,要么对整个基因组进行测序。”
In 1986, Renato Dulbecco, a pioneer in cancer research, declared in Science: “If we want to know more about cancer, then we must now concentrate on the cell’s genome. Is at a turning point. ”The Nobel Prize winner more than two decades ago was the earliest public initiative to become a human genome project in the future. The research results accumulated in previous years have made people understand that the massive derailment of cancerous cells mostly comes from the damage to the cellular gene and the change of function. He wrote: “We have two options, either to try to find genes that play an important role in malignancy, or to sequence the entire genome.” "