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地高辛在临床上多用于具有生命危险的病人,地高辛制剂生物利用度的不一致性导致药物毒性增加或者疗效降低。影响地高辛片生物利用度的因素很多。据报告,在片剂制备过程中,即使对药物粉末质点的大小加以很好控制,成品的绝对生物利用度也只能达到60~80%。此外,药物相互作用也是影响地高辛生物利用度的重要因素。为了改善地高辛口服的生物利用度,近年来广泛采用地高辛溶液制成的软明胶胶丸,该胶丸剂的
Digoxin in clinical use for life-threatening patients, digoxin bioavailability inconsistencies lead to increased drug toxicity or reduced efficacy. Many factors affect the bioavailability of digoxin tablets. It has been reported that the absolute bioavailability of the finished product can only reach 60 to 80% even during the tablet preparation process, even if the particle size of the drug powder is well controlled. In addition, drug interactions are also important factors that affect the bioavailability of digoxin. In order to improve the oral bioavailability of digoxin, in recent years, widely used digoxin solution made of soft gelatin capsules, the