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目的 探讨伍用硝苯吡啶治疗儿童紫癜性肾炎 (APN)的可能作用机制。方法 10 3例APN患儿 ,按入院日期 (单双日 )分为伍用硝苯吡啶治疗组 63例和常规治疗组 40例 ,另设正常健康儿童组 3 0例。治疗前、治疗 4～ 6周后分别测定血液流变学参数。结果 APN患儿呈现血液高凝状态 ,动态观察常规治疗组患儿血液流变学参数改善不明显 ,而伍用硝苯吡啶治疗组则改善明显 ;硝苯吡啶可明显提高APN的治愈率。结论 伍用硝苯吡啶能明显改善APN患儿的血液流变学参数 ,这可能是其治疗APN的作用机制之一
Objective To investigate the possible mechanism of Nifedipine in the treatment of purpuric nephritis (APN) in children. Methods A total of 63 children with APN were divided into nifedipine treatment group (n = 63) and conventional treatment group (n = 40) according to the admission date (single and double days). Another 30 healthy children were enrolled. Before treatment, hemorrheological parameters were measured after 4 to 6 weeks of treatment. Results The blood hypercoagulability was observed in children with APN. No significant improvement was found in the parameters of hemorheology in routine treatment group, while those in nifedipine treatment group were significantly improved. Nifedipine significantly improved the cure rate of APN. Conclusion Nifedipine can significantly improve hemorrheological parameters in children with APN, which may be one of its mechanisms of action in treating APN