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通过施行大鼠B Ⅱ式胃部分切除 (胃空肠吻合 )术形成胆汁反流性胃炎 ,观察柴芩平胃胶囊对胃肠激素和胃液pH的影响 ,分析其治疗残胃炎的作用机理。结果 :与空白组比较 ,模型组大鼠血清胃泌素 (Gastrin)和胃粘膜前列腺素E2 (PGE2 )显著降低 (P <0 0 1 ) ,胃液pH升高 (P <0 0 1 )。与模型组比较 ,柴芩平胃胶囊小、中剂量组可升高血清胃泌素、胃液表皮生长因子 (EGF)和PGE2 (P<0 0 5 ) ,但对胃液pH影响不大。说明长期胆汁反流可引起胃肠内分泌激素的失调 ,损伤胃粘膜营养和防御机能 ,从而损伤胃粘膜 ;柴芩平胃胶囊通过影响激素分泌而达到治疗目的。
Bile regurgitant gastritis was established by the use of a rat B-type partial gastrectomy (gastrojejunostomy) to observe the effects of Chaiqin Pingwei Capsule on gastrointestinal hormones and pH of gastric juice, and the mechanism of its action on residual gastritis was analyzed. RESULTS: Compared with the blank group, the rats in the model group had significantly decreased gastrin (Gastrin) and gastric mucosal prostaglandin E2 (PGE2) (P <0 01) and increased gastric pH (P <0 01). Compared with the model group, Chai Qin Ping Wei capsule small and medium dose group can increase serum gastrin, gastric epidermal growth factor (EGF) and PGE2 (P <0 05), but has little effect on gastric juice pH. It shows that long-term bile reflux can cause imbalance of gastrointestinal endocrine hormones, damage nutrition and defense function of gastric mucosa, thus injuring the gastric mucosa; Chai Qin Pingwei capsule can achieve therapeutic goals by affecting hormone secretion.