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采用4血管关闭方法阻断新西兰白兔脑部血流,造成急性全脑缺血性实验模型。经伊文氏兰及光镜方法对脑组织进行了形态学观察。同时经放免力法观察了血栓环素动态的变化。实验证实该方法所致缺血模型是成功的;不同时间间隔的血栓环素增多呈持续性,不同时期的病理改变吻合了急性脑缺血的基本病理过程。反复血管及心脏取血表明该模型对实施血浆多种微量及超微量物质的血液学检查是适宜的。
A 4-vessel occlusion method was used to block the flow of brain in New Zealand white rabbits, resulting in an experimental model of acute global cerebral ischemia. Morphological observation of brain tissue was performed by means of Evans blue and light microscope. At the same time, the dynamic changes of thromboxanin were observed by radioimmunoassay. Experiments confirmed that the method of ischemia model was successful; different intervals of thromboxanin increased was persistent, different pathological changes consistent with the basic pathological process of acute cerebral ischemia. Repeated blood vessels and blood from the heart indicate that the model is suitable for performing hematological examinations of multiple trace and ultramicro substances in plasma.