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为了探寻急性肺损伤早期有提示意义的指标,我们给狗静脉注射油酸造成急性肺损伤模型。发现油酸注入后30分钟,静脉—动脉血中5-HT含量的差值明显下降;动脉血中ACE活性在注油酸后5分钟即显著下降。讨论了这两项结果的变化可作为肺毛细血管内皮细胞早期受损的指示性指标。
In order to explore the early indicators of acute lung injury suggestive of the significance, we give dogs intravenous oleic acid caused acute lung injury model. After 30 minutes of oleic acid injection, the difference of 5-HT level in venous-arterial blood was significantly decreased. The ACE activity in arterial blood decreased significantly 5 minutes after oleic acid injection. It is discussed that the changes of these two results can be used as an indicator of early damage of pulmonary capillary endothelial cells.