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21例重症心衰患者,于胸部贴用透皮硝酸甘油制剂(TTS-NTG)1块(含硝酸甘油25mg/10cm~2),观察血流动力学、自觉症状及其他体征。若效果不佳,24小时后(第2天)改用含量为50mg/10cm~2的贴剂1块。治疗期间,观察副作用及临床检验变化。用药后24小时的血流动力学评价,16例肺动脉舒张压(dPA)>18mmHg以上者获得显著的临床疗效,dPA从平均26.7±2.1 mmHg降至用药1小时后的22.7±1.6mmHg(p<0.01),本效应维持24小时;心脏指数从平均每分钟2.42±0.13 L/m~2增至
Twenty-one patients with severe heart failure were treated with transdermal nitroglycerin (TTS-NTG) 1 (containing nitroglycerin 25mg / 10cm ~ 2) on the chest to observe the hemodynamics, symptoms and other signs. If the effect is not good, after 24 hours (day 2) use a patch content of 50mg / 10cm ~ 2 1. During treatment, side effects and clinical changes were observed. Significant clinical efficacy was obtained at 16 hours after dosing from 16.7 ± 2.1 mmHg for dPA and 22.7 ± 1.6 mmHg after 1 hour of treatment (p < 0.01). The effect was maintained for 24 hours. The heart index increased from 2.42 ± 0.13 L / m ~ 2