论文部分内容阅读
为构建食蟹猴T2DM进程序列模型,将36只食蟹猴分为4组,分别采用标准基础膳食和高能量膳食(高糖膳食、高脂膳食和高糖高脂膳食)进行诱导,每6个月测量体重、血液生化指标、口服糖耐量和尿检试验。结果显示,高能量膳食组的血糖、血脂水平与初期相比,都有显著升高。其中高糖组的T2DM发病进程较快,高糖高脂组的发病进程相对较慢,但发病进程大致相同。在T2DM临床期之前,不同膳食组在相同发病阶段血脂水平存在差异,至临床期差异消失。根据结果可得,不同膳食成分的高能量膳食均能诱发食蟹猴T2DM进程序列模型,该序列模型是模拟自发型糖尿病发病机理构建的较理想T2DM动物模型。
To construct the sequence model of T2DM in cynomolgus monkey, 36 cynomolgus monkeys were divided into 4 groups, which were induced by standard basic diet and high energy diet (high-sugar diet, high-fat diet and high-fat diet) Month weight, blood biochemical indicators, oral glucose tolerance and urine test. The results showed that high-energy diet group, blood glucose, blood lipid levels were significantly higher than the initial. Among them, the incidence of T2DM in high glucose group was faster, and the incidence of T2DM in high glucose and high fat group was relatively slow, but the course of onset was almost the same. Before the clinical stage of T2DM, different dietary groups had different blood lipid levels at the same stage of disease, and the difference disappeared at the clinical stage. According to the results, high-energy diet with different dietary components can induce T2DM process model of cynomolgus monkey, which is an ideal T2DM animal model to simulate the pathogenesis of spontaneous diabetes mellitus.