随机对照试验的证据表明,心血管病高危患者用羟甲基戊二酰辅酶A还原酶抑制剂(他汀)治疗降低低密度脂蛋白胆固醇可降低缺血性卒中的发病率。不过,来自大型流行病学观察性研究的资料却表明,出血性卒中风险与胆固醇水平之间存在相反的联系。美国密西西比大学药学院的Henyan等进行? Evidence from randomized controlled trials suggests that treatment with hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) in patients at high risk of cardiovascular disease reduces the incidence of ischemic stroke by lowering LDL cholesterol. However, data from a large epidemiological observational study suggest that there is an inverse relationship between the risk of hemorrhagic stroke and cholesterol levels. Henyan at the University of Mississippi School of Pharmacy