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目的:观察小剂量肝素治疗妊娠期肌瘤红色变性的疗效。方法:选择21例有临床症状的妊娠期肌瘤红色变性患者作为研究对象,对其临床资料进行回顾性分析。21例患者按治疗方法分为研究组12例和对照组9例,均行静脉滴注硫酸镁和抗生素等保守治疗,其中研究组加用小剂量肝素静脉滴注,观察并对比两组的疗效。结果:两组均未发生因肌瘤红色变性所诱发的早产、流产,亦无单纯行急诊肌瘤切除术者。研究组腹痛减轻、腹痛缓解、宫缩消失和体温正常时间均显著短于对照组,组间比较差异有统计学意义(P<0.05)。研究组治疗期间凝血功能检查无明显异常。结论:联合应用小剂量肝素治疗妊娠期肌瘤红色变性的效果优于单用硫酸镁和抗生素,值得临床推广使用。
Objective: To observe the effect of low dose heparin in treating red degeneration of myoma of pregnancy. Methods: Twenty-one patients with clinical symptoms of myoma red degeneration were selected as the research object, and their clinical data were retrospectively analyzed. Twenty-one patients were divided into study group (n = 12) and control group (n = 9) according to the method of treatment. All patients underwent conservative treatment with intravenous dripping of magnesium sulfate and antibiotics. The study group was treated with intravenous drip of low-dose heparin and observed and compared the curative effect . Results: There was no premature labor or miscarriage induced by red degeneration of myoma in either group. In the study group, the reduction of abdominal pain, the relief of abdominal pain, the disappearance of uterine contractions and the normal body temperature were significantly shorter than those in the control group. There was significant difference between the two groups (P <0.05). Study group during the coagulation test no significant abnormalities. Conclusion: The combined application of low-dose heparin in the treatment of redness of myoma during pregnancy is better than single magnesium sulfate and antibiotics, worthy of clinical promotion.