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目的 探讨大剂量四氢叶酸钙(HDCF)与5—氟脲嘧啶(5—Fu)联合顺铂(DDP)治疗晚期胃肠道肿瘤的临床疗效。方法 28例中胃癌10例,结直肠癌18例,CF300mg静滴2小时,连用5天,5—Fu 500mg于CF滴完后立即静滴,连用5天,DDP30mg静滴,连用3天。结果 总有效率(CR+PR)57.1％,胃癌与结直肠癌的有效率为50％和61％。主要毒副作用为恶心、呕吐、静脉炎和Ⅰ～Ⅱ骨髓抑制。结论 该方案毒性低,近期疗效满意,可作为晚期胃肠道癌的治疗方法。
Objective To investigate the clinical efficacy of high-dose tetrahydrofolate (HDCF) and 5-fluorouracil (5-Fu) combined with cisplatin (DDP) in the treatment of advanced gastrointestinal cancer. Methods 28 cases of gastric cancer in 10 cases, 18 cases of colorectal cancer, CF300mg intravenous infusion for 2 hours, used for 5 days, 5-Fu 500mg infusion immediately after the completion of CF infusion, continuous use for 5 days, DDP30mg intravenous infusion for 3 days. Results The total effective rate (CR+PR) was 57.1%, and the effective rates of gastric cancer and colorectal cancer were 50% and 61%. The main toxic side effects were nausea, vomiting, phlebitis and I-II bone marrow suppression. Conclusions The program has low toxicity and satisfactory curative effect. It can be used as a treatment for advanced gastrointestinal cancer.