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目的 :观察银杏叶提取物 (杏丁 )对急性脑梗塞患者血浆 von Willebrand因子 (v WF)和血栓调节蛋白(TM)的影响 ,从而了解其对内皮细胞的保护作用。方法 :34例急性脑梗塞患者随机分为两组 :实验组 ,n=17,每日静脉滴杏丁 2 0 ml,连续 14 d;对照组 ,n=17,每日静脉滴注复方丹参注射液 2 5 0 ml,于治疗前、治疗后 7d、 14 d检测两组患者血浆 v WF和 TM的水平变化。结果 :两组患者血浆 v WF和 TM治疗前均无显著性差异 (P>0 .0 5 ) ,治疗后第 7d、14 d实验组 v WF明显低于对照组 (P<0 .0 5 ) ,且两组患者治疗后均低于治疗前 ((P<0 .0 5或 P<0 .0 1) ;治疗后第 7d实验组 TM明显高于对照组 (P<0 .0 5 ) ,且两组患者治疗后均高于治疗前 (P<0 .0 5或 P<0 .0 1)。结论 :银杏叶提取物(杏丁 )可明显降低急性脑梗塞患者血浆 v WF和提高 TM水平 ,有益于保护内皮细胞的功能
OBJECTIVE: To observe the effect of Ginkgo biloba extract on von Willebrand factor (v WF) and thrombomodulin (TM) in patients with acute cerebral infarction and to understand its protective effect on endothelial cells. Methods: Thirty-four patients with acute cerebral infarction were randomly divided into two groups: experimental group, n = 17, daily intravenous infusion of apricot 20 ml for 14 days; control group, n = 17, Liquid 2550ml, before treatment, 7d, 14d after treatment, the plasma vWF and TM levels in two groups were measured. Results: There was no significant difference between vWF and TM before treatment in both groups (P> 0.05). The vWF of the experimental group on the 7th and 14th day after treatment was significantly lower than that of the control group (P <0.05) (P <0.05 or P <0.01). After treatment, TM in the experimental group was significantly higher than that in the control group (P <0.05) (P <0.05 or P <0.01) .Conclusion: Ginkgo biloba extract (Xingding) can significantly reduce the plasma vWF in patients with acute cerebral infarction and improve the TM Level, beneficial to protect the function of endothelial cells