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目的研究联合检测血清CEA、CA199水平对非小细胞肺癌术后复发转移及预后的临床预测价值。方法对61例非小细胞肺癌患者术前血清CEA、CA199水平联合检测,术后水平的动态监测,分析两者对肺癌术后复发转移及预后的临床预测价值。结果单因素分析显示术前CEA、CA199水平高于正常的阳性组中,患者年龄偏高,术前体重下降明显,临床分期较晚,术后易发生复发转移,无疾病生存期较短,与阴性组相比差异有统计学意义(P<0.05);而在性别、体能状态等方面两组差异无统计学意义(P>0.05);生存分析显示,阳性组患者预后差,无疾病生存期短,与阴性组相比差异有统计学意义(P<0.05)。在对复发转移患者的动态监测过程中,14例术后首次出现血清肿瘤标志物升高的时间要早于客观检查证实为复发转移,并逐渐缓慢上升直至复发转移,平均提前6个月;另有10例患者复发转移时肿瘤标志物数值较前次突然大幅度增高,平均增高7.47倍。结论联合检测非小细胞肺癌患者术前血清CEA、CA199水平,动态监测,可以作为肺癌术后复发转移预测及预后的有效指标。
Objective To study the clinical predictive value of combined detection of serum CEA and CA199 levels in postoperative recurrence, metastasis and prognosis of non-small cell lung cancer. Methods 61 cases of non-small cell lung cancer patients with preoperative serum levels of CEA, CA199 joint detection and postoperative levels of dynamic monitoring, analysis of both the recurrence, metastasis and prognosis of lung cancer clinical prediction. Results Univariate analysis showed that the preoperative levels of CEA and CA199 were higher than those in the normal group. The patients were older, the preoperative weight loss was significant, the clinical stage was late, the recurrence and metastasis was easily occurred, the disease free survival was short, (P <0.05). There was no significant difference in gender and physical status between the two groups (P> 0.05). Survival analysis showed that patients in the positive group had poor prognosis and no disease-free survival Short, compared with the negative group was statistically significant (P <0.05). In the dynamic monitoring of patients with recurrent metastasis, the first time after 14 patients with serum tumor markers increased as early as the objective examination confirmed the recurrence and metastasis, and gradually increased slowly until recurrence and metastasis, an average of 6 months earlier; Ten patients with recurrence and metastasis tumor markers a sudden sharp increase in value compared with the previous, with an average increase of 7.47 times. Conclusions The combined detection of preoperative serum CEA and CA199 levels and dynamic monitoring in patients with non-small cell lung cancer can be used as an effective indicator of postoperative recurrence and metastasis and prognosis of patients with lung cancer.