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H_2受体阻滞剂甲氰咪胍(cimetidine)目前已广泛应用于治疗十二指肠溃疡、胃溃疡及胃粘膜糜烂等疾病,至今全世界至少有数千万患者服用过甲氰咪胍。与此同时,在甲氰咪胍治疗过程中也发现一些不良反应或副作用。美国调查9907例服用甲氰咪胍的患者,仅发现24例有副作用。因消化性溃疡进行短程治疗的2182例中,约1.5％因副作用需停用甲氰咪胍。部分患者可出现轻度腹泻、肌痛、头晕、皮疹、嗜睡或男性乳房发育等副作用。本文扼要介绍申氰咪胍临床应用过程中的副作用,以引起重视和注意。甲氰咪胍的药理作用
H 2 receptor blocker cimetidine has been widely used in the treatment of duodenal ulcer, gastric ulcer and gastric mucosal erosion and other diseases. Till now, at least tens of millions of patients in the world have taken cimetidine. At the same time, some side effects or side effects were also found during cimetidine treatment. The United States investigated 9,909 patients taking cimetidine and found only 24 patients with side effects. About 1.5% of the 2182 cases of short-course treatment of peptic ulcer due to side effects need to discontinue cimetidine. Some patients may be mild diarrhea, myalgia, dizziness, rash, drowsiness or male breast development and other side effects. This article briefly describes the side effects of the application of cimetidine in clinical applications to attract attention and attention. Cimetidine pharmacological effects