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苯(口恶)洛芬自1980年用苯(口恶)洛芬抗风湿治疗不到两年,因在老年人中出现意想不到的死亡而停用。此种毒性在原先有肝、肾疾病,又同时应用髓袢利尿剂的身材矮小的女性表现得尤为严重。毒性可能是因以下两个因素合并存在所致,一是肾脏疾病引起的血浆半衰期延长,二是由于药物在胆小管内沉淀并阻塞胆小管所致。使用苯(口恶)洛芬的经验证明,与青年人相比,老年人对药物的反应方式有很大差异。阿司匹林的毒性由阿司匹林产物引起的CNS 毒性的典型表现为可逆性双侧听力丧失或耳鸣。由于阿司匹林毒性的早期症状缺乏或未被认识,老年人常表现为突然出现严重阿司
Benzene (Oral Efficacy) Lupine has been used for less than two years in 1980 with phenylephrine anti-rheumatoid (benzene) and is discontinued due to unexpected deaths among the elderly. This toxicity in the original liver and kidney disease, but also the application of diarrhea, diarrhea, sturdy body of women is particularly serious. Toxicity may be due to the combination of the following two factors, one is due to prolonged plasma half-life due to kidney disease and the other is due to drug precipitation in the bile duct and obstruction of the bile duct. Experience with benzophenone (Loxoprofen) has shown that older people respond differently to drugs than young people. Aspirin Toxicity A typical manifestation of CNS toxicity caused by aspirin products is reversible bilateral hearing loss or tinnitus. Because of the early symptoms of aspirin toxicity is lacking or unknown, the elderly often appear as a sudden severe Asi