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为了解抗生素渗透胰组织的能力，以便为选择合适的抗生素治疗继发性胰腺感染提供参考依据。作者在建立犬急性出血坏死性胰腺炎（ＡＨＮＰ）模型的基础上，应用高效液相色谱法测定犬血清和胰组织中抗生素的浓度，并计算出它们的胰组织渗透率。结果：头孢噻肟、氧氟沙星、丁胺卡那霉素、氧哌嗪青霉素、头孢哌酮、氨苄青霉素、甲硝唑和环丙沙星的胰组织渗透率由小到大依次为１２％、１９％、２０％、４６％、５５％、６３％、７１％和１３２％。本实验结果提示：各抗生素的胰组织渗透能力差别较大，临床医师应选用渗透胰组织能力强的抗生素治疗继发性胰腺感染
To understand the ability of antibiotics to penetrate the pancreatic tissue in order to provide a reference for the selection of appropriate antibiotics for the treatment of secondary pancreatic infection. Based on the establishment of a model of acute hemorrhagic necrotizing pancreatitis (AHNP) in dogs, the authors measured the concentrations of antibiotics in canine serum and pancreatic tissues by high performance liquid chromatography (HPLC) and calculated their pancreatic permeability. Results: The permeabilities of cefotaxime, ofloxacin, amikacin, piperacillin, cefoperazone, ampicillin, metronidazole and ciprofloxacin were 12 %, 19%, 20%, 46%, 55%, 63%, 71% and 132%. The results of this experiment suggest that there is a great difference in the ability of each antibiotic to penetrate the pancreatic tissue. Clinicians should choose antibiotics that have the ability to penetrate the pancreatic tissue to treat secondary pancreatic infections