论文部分内容阅读
目的探讨妊娠糖尿病(GDM)孕妇静脉血及新生儿脐带血中血糖(Glu)、糖化血红蛋白(HbA1c)水平的相关性。方法应用葡萄糖氧化酶法和琼脂糖凝胶电泳法分别检测观察组和对照组孕妇静脉血及新生儿脐带血中的Glu和HbA1c水平,并进行分析。结果观察组孕妇静脉血Glu和HbA1c水平明显高于对照组,差异有统计学意义(P<0.01)。但其新生儿脐带血与对照组相比,Glu水平差异无统计学意义(P>0.05),HbA1c水平差异有统计学意义(P<0.01)。观察组新生儿脐带血HbA1c水平明显高于其母血HbA1c水平,差异有统计学意义(P<0.01);而对照组新生儿脐带血HbA1c水平较其母血HbA1c水平,差异无统计学意义(P>0.05)。结论孕期母体摄入的糖分直接决定了新生儿脐带血中的Glu和HbA1c水平,且孕妇摄入过量的糖分对胎儿造成的影响更大。
Objective To investigate the relationship between blood glucose (Glu) and glycosylated hemoglobin (HbA1c) levels in umbilical cord blood of pregnant women with gestational diabetes mellitus (GDM) and neonates. Methods Glucose oxidase and agarose gel electrophoresis were used to detect the level of Glu and HbA1c in the umbilical cord blood of pregnant women and the pregnant women in observation group and control group respectively. Results The levels of Glu and HbA1c in the pregnant group were significantly higher than those in the control group (P <0.01). However, there was no significant difference in the levels of Glu between the neonatal umbilical cord blood and the control group (P> 0.05). There was a significant difference in HbA1c levels between the two groups (P <0.01). The level of HbA1c in neonatal umbilical cord blood in observation group was significantly higher than that in maternal blood, the difference was statistically significant (P <0.01); while the level of HbA1c in neonatal umbilical cord blood in control group was not significantly different from that of maternal blood HbA1c P> 0.05). Conclusion The maternal intake of sugars in pregnancy directly determines the levels of Glu and HbA1c in the umbilical cord blood of pregnant women, and the excessive intake of sugar by pregnant women has a greater impact on the fetus.