西藏大骨节病的临床表现与内地有很大差异,表现为大关节的严重畸形,其中尤以下肢为重,重者导致瘫痪。而且大骨节病有新的临床亚型,既往未被人们所认识。其临床表现特殊,即以“肱骨短小、身材矮小和手足正常”为主要临床表现。本文讨论了西藏大骨节病临床病变的可能原因及大骨节病新临床亚型在病因研究、病情监测和现场防治的流行病学意义。 The clinical manifestations of Kashin-Beck disease in Tibet are quite different from those in the Mainland. They show severe deformities in the joints, especially in the lower extremities. Severe cases lead to paralysis. And Kashin-Beck disease has a new clinical subtype, not previously known by people. The clinical manifestations of special, that is, “short humerus, short stature and hand, foot normal” as the main clinical manifestations. This article discusses the possible causes of Kashin-Beck disease in Tibet and the epidemiological significance of the new clinical subtype of Kashin-Beck disease in etiology, disease surveillance and field control.